Detalhe da pesquisa
1.
Machine learning estimation of human body time using metabolomic profiling.
Proc Natl Acad Sci U S A
; 120(18): e2212685120, 2023 05 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-37094145
2.
Effect of acute total sleep deprivation on plasma melatonin, cortisol and metabolite rhythms in females.
Eur J Neurosci
; 51(1): 366-378, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30929284
3.
Metabolomic changes of the multi (-AGC-) kinase inhibitor AT13148 in cells, mice and patients are associated with NOS regulation.
Metabolomics
; 16(4): 50, 2020 04 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-32285223
4.
International Ring Trial of a High Resolution Targeted Metabolomics and Lipidomics Platform for Serum and Plasma Analysis.
Anal Chem
; 91(22): 14407-14416, 2019 11 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-31638379
5.
Characterisation of CCT271850, a selective, oral and potent MPS1 inhibitor, used to directly measure in vivo MPS1 inhibition vs therapeutic efficacy.
Br J Cancer
; 116(9): 1166-1176, 2017 Apr 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-28334731
6.
Pyrido[3,4-d]pyrimidin-4(3H)-one metabolism mediated by aldehyde oxidase is blocked by C2-substitution.
Xenobiotica
; 47(9): 771-777, 2017 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-27618572
7.
Effect of sleep deprivation on the human metabolome.
Proc Natl Acad Sci U S A
; 111(29): 10761-6, 2014 Jul 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-25002497
8.
Synthesis and Evaluation of a 2,11-Cembranoid-Inspired Library.
Chemistry
; 22(16): 5657-64, 2016 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-26929153
9.
Discovery of potent and selective CDK8 inhibitors from an HSP90 pharmacophore.
Bioorg Med Chem Lett
; 26(5): 1443-51, 2016 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26852363
10.
7-(Pyrazol-4-yl)-3H-imidazo[4,5-b]pyridine-based derivatives for kinase inhibition: Co-crystallisation studies with Aurora-A reveal distinct differences in the orientation of the pyrazole N1-substituent.
Bioorg Med Chem Lett
; 25(19): 4203-9, 2015 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26296477
11.
Dependence of Wilms tumor cells on signaling through insulin-like growth factor 1 in an orthotopic xenograft model targetable by specific receptor inhibition.
Proc Natl Acad Sci U S A
; 109(20): E1267-76, 2012 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22529373
12.
Design, Synthesis, and Evaluation of Inhibitors of Hedgehog Acyltransferase.
J Med Chem
; 67(2): 1061-1078, 2024 Jan 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-38198226
13.
Erratum to: investigation of metabolites for estimating blood deposition time.
Int J Legal Med
; 132(1): 33, 2018 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28840223
14.
HSF1 Pathway Inhibitor Clinical Candidate (CCT361814/NXP800) Developed from a Phenotypic Screen as a Potential Treatment for Refractory Ovarian Cancer and Other Malignancies.
J Med Chem
; 66(8): 5907-5936, 2023 04 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-37017629
15.
Discovery of an In Vivo Chemical Probe for BCL6 Inhibition by Optimization of Tricyclic Quinolinones.
J Med Chem
; 66(8): 5892-5906, 2023 04 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-37026591
16.
Presence of human breast cancer xenograft changes the diurnal profile of amino acids in mice.
Sci Rep
; 12(1): 1008, 2022 01 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-35046467
17.
FGF7-FGFR2 autocrine signaling increases growth and chemoresistance of fusion-positive rhabdomyosarcomas.
Mol Oncol
; 16(6): 1272-1289, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34850536
18.
Discovering cell-active BCL6 inhibitors: effectively combining biochemical HTS with multiple biophysical techniques, X-ray crystallography and cell-based assays.
Sci Rep
; 12(1): 18633, 2022 11 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36329085
19.
Repurposing Vandetanib plus Everolimus for the Treatment of ACVR1-Mutant Diffuse Intrinsic Pontine Glioma.
Cancer Discov
; 12(2): 416-431, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34551970
20.
Optimizing Shape Complementarity Enables the Discovery of Potent Tricyclic BCL6 Inhibitors.
J Med Chem
; 65(12): 8169-8190, 2022 06 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-35657291